Cisplatin electrolyte abnormalities

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August undefined, 2024

WebDec 16, 2024 · However, cisplatin-induced nephrotoxicity is a major dose-limiting factor and a significant adverse event. Mannitol is used to reduce cisplatin-induced nephrotoxicity, which is controversial. ... Diuretics contribute to electrolyte disorders, often promoting the excretion of electrolytes into urine by the kidneys. In this meta … WebManufacturer advises cisplatin requires intensive intravenous hydration and treatment may be complicated by severe nausea and vomiting. ... Side-effects Side-effects For cisplatin. Common or very common. Anaemia; arrhythmias; bone marrow failure; electrolyte imbalance; extravasation necrosis; fever; leucopenia; nephrotoxicity (dose-related and ...

Gitelman-like syndrome after cisplatin therapy: a case report and ...

WebOct 19, 2024 · Severe electrolyte abnormalities (secondary exposure) included ≥ grade three hypophosphatemia, hypokalemia, or hypomagnesemia (National Cancer Institute Common Terminology Criteria for Adverse Events v4.0). CKD was albuminuria or decreased kidney function for age (KDIGO guidelines). WebMay 1, 2024 · The most common diagnoses were central nervous system tumors (58 [36%]), neuroblastoma (43 [27%]), and osteosarcoma (33 [21%]). Acute kidney injury (by serum creatinine level increase) occurred in 48 of 159 patients (30%) at early cisplatin infusions and 23 of 143 patients (16%) at late cisplatin infusions. dan the song parody man

Electrolyte Disorders Induced by Antineoplastic Drugs

WebJun 8, 2024 · Cisplatin injection can cause dose-related peripheral neuropathy that becomes more severe with repeated courses of the drug. Neurologic symptoms have … WebOct 19, 2024 · In the literature, cisplatin-associated electrolyte abnormalities are poorly described, but hypomagnesemia occurs in 14–94% of children [3, 4, 36, 38, 39]. CNS … WebMar 1, 2024 · A case of an elderly male presenting with significant recurrent hyponatremia, and prerenal azotemia, with recent exposure to cisplatin along with significant hypovolemia and urinary loss of sodium is reported. Cisplatin is a well‐known chemotherapeutic agent that can be associated with hyponatremia. It is known to be associated with a multitude … dan the spa man spas years in business

Electrolyte disorders associated with the use of anticancer drugs

WebSep 15, 2024 · Cisplatin is administered parenterally and is available in 50 and 100 mg vials in generic forms and under the brand name Platinol. The recommended dose varies by indication, tumor type, patient age and body weight. Common side effects include nausea, vomiting, bone marrow suppression, electrolyte imbalance, neuropathy, ototoxicity and ... WebSep 18, 2024 · NCBI Bookshelf dan the songWebNov 1, 2024 · Special attention needs to be paid to electrolyte disturbances, which should be particularly considered when administering high doses of cisplatin [19]. The most common electrolyte disorder is ... birthday spots nyc

"WebFeb 16, 2024 · Common side effects of cisplatin may include: hearing problems; kidney problems; numbness or tingling; nausea, vomiting; or. bone marrow suppression. This is … " - Cisplatin electrolyte abnormalities

Cisplatin electrolyte abnormalities

Profound hyponatremia and dehydration: A case of cisplatin …

WebJul 28, 2024 · Electrolyte Abnormalities: This medication can affect the normal levels of electrolytes (potassium, magnesium, calcium, etc.) in your body. Your levels will be … WebMay 18, 2024 · Amphotericin B is used in the treatment of often life-threatening fungal infections (see "Pharmacology of amphotericin B"). Impaired kidney function is a …

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http://www.ejmanager.com/mnstemps/93/93-1446132625.pdf#:~:text=The%20most%20common%20electrolyte%20abnormality%20associated%20with%20cisplatin,the%20incidence%20of%20which%20varies%20significantly%20between%20studies. WebDec 9, 2024 · Electrolyte disorders are very common conditions in cancer patients. They mainly concern changes in serum sodium, potassium, calcium, and magnesium levels. In most cases, these alterations are asymptomatic and therefore not always taken into consideration in clinical practice.

WebJul 28, 2024 · Electrolyte Abnormalities: This medication can affect the normal levels of electrolytes (potassium, magnesium, calcium, etc.) in your body. Your levels will be monitored using blood tests. If your levels become too low, your care team may prescribe specific electrolytes to be given by IV or taken by mouth. WebJan 3, 2024 · A variety of kidney diseases and electrolyte disorders can result from the drugs that are used to treat malignant disease, including conventional cytotoxic agents; molecularly targeted agents, which take advantage of molecular abnormalities that drive cancer progression; and immunotherapeutic agents.

Webcisplatin, and was severe in 20%. Monitor patients for hypomagnesemia, hypocalcemia, and hypokalemia prior to each dose of PORTRAZZA during treatment and for at least 8 weeks following completion of PORTRAZZA. Withhold PORTRAZZA for Grade 3 or 4 electrolyte abnormalities. Replete electrolytes as medically appropriate. (5.2) WebCisplatin can cause increased magnesium losses by the kidneys as well as generalized decrease in kidney function. Magnesium loses can be severe and persist despite discontinuation of cisplatin. Discontinuation of cisplatin is still recommended if signs of renal toxicity occur during therapy. Table Causes of Hypomagnesemia

WebHypomagnesemia occurred in 83% of patients receiving PORTRAZZA in combination with gemcitabine and cisplatin, and was severe in 20% of patients. Monitor patients for hypomagnesemia, hypocalcemia, and hypokalemia prior to each dose of PORTRAZZA during treatment and for at least 8 weeks following completion of PORTRAZZA.

WebCisplatin is a coordinate metal complex with significant antineoplastic activity and various effects, including acute anc chronic renal insufficiency and renal magnesium … dan the spa man deathWebFrequency not known. Alopecia; appetite decreased; asthenia; autonomic dysfunction; cardiac disorder; cerebrovascular insufficiency; deafness; dehydration; diarrhoea; … birthday squad shirts for kidsWebSep 27, 2024 · Nephrotoxicity: cisplatin for injection can cause severe renal toxicity, including acute renal failure. Severe renal toxicities are dose-related and cumulative. Ensure adequate hydration and monitor renal function and electrolytes. dan the smoke detector manWeb• Hypomagnesemia and Accompanying Electrolyte Abnormalities: Monitor during treatment and for at least 8 weeks following the completion. Replete electrolytes as necessary. (5.6) ... and Cisplatin . 5.6 Hypomagnesemia and Accompanying Electrolyte Abnormalities . 5.7 Increased Tumor Progression, Increased Mortality, or Lack ... dan the spa man wichita ksWebJun 10, 2024 · However, cisplatin is known to cause a variety of adverse effects (such as nausea and vomiting, renal insufficiency, electrolyte abnormalities, myelosuppression, ototoxicity, peripheral neuropathy, hepatotoxicity, and retinopathy) than other chemotherapy regimens. Diarrhea, pancreatitis, seizures, and respiratory failure have also been reported. dan the son of jacobWebmay drive unique electrolyte disorders in different malignancies. In the next sections, the clinical fea-tures, pathophysiology, and treatment of the most … birthdaysrus.comWebMay 18, 2024 · Compared with young patients, the incidences of cisplatin-induced nephrotoxicity and acute kidney injury (AKI) in elderly patients are significantly increased, … birthday squad toy story svg